| Date | Home | Away | Group | Result |
|---|---|---|---|---|
| 01/04/25 23:00 | Club Cerro Porteno | Club Bolívar | Group G | --- |
| 01/04/25 23:00 | Carabobo FC | Estudiantes de La Plata | Group A | --- |
| 02/04/25 01:30 | Fortaleza | Racing Club | Group E | --- |
| 02/04/25 01:30 | Atlético Bucaramanga | Colo-Colo | Group E | --- |
| 02/04/25 03:00 | Alianza Lima | Club Libertad | Group D | --- |
| 02/04/25 03:00 | Barcelona SC | Independiente del Valle | Group B | --- |
| 02/04/25 23:00 | CA Velez Sarsfield | Club Atlético Peñarol | Group H | --- |
| 02/04/25 23:00 | San Antonio Bulo Bulo | Club Olimpia | Group H | --- |
| 03/04/25 01:30 | CA Talleres | FC Sao Paulo | Group D | --- |
| 03/04/25 01:30 | Universitario | River Plate | Group B | --- |
| 03/04/25 01:30 | Universidad de Chile | Botafogo | Group A | --- |
| 03/04/25 03:00 | Atlético Nacional | Club Nacional de Football | Group F | --- |
| 03/04/25 23:00 | Sporting Cristal | Palmeiras | Group G | --- |
| 03/04/25 23:00 | Bahia BA | Internacional | Group F | --- |
| 03/04/25 23:00 | Central Cordoba | LDU Quito | Group C | --- |
| 04/04/25 01:30 | Deportivo Tachira | Flamengo | Group C | --- |