| Date | Home | Away | Group | Result |
|---|---|---|---|---|
| 08/04/25 23:00 | Club Libertad | CA Talleres | Group D | 2-0 |
| 08/04/25 23:00 | Botafogo | Carabobo FC | Group A | 2-0 |
| 09/04/25 01:00 | Club Atlético Peñarol | San Antonio Bulo Bulo | Group H | 2-0 |
| 09/04/25 01:30 | River Plate | Barcelona SC | Group B | 0-0 |
| 09/04/25 01:30 | Estudiantes de La Plata | Universidad de Chile | Group A | 1-2 |
| 09/04/25 03:00 | Independiente del Valle | Universitario | Group B | 1-0 |
| 09/04/25 23:00 | Club Olimpia | CA Velez Sarsfield | Group H | 0-4 |
| 09/04/25 23:00 | Club Nacional de Football | Bahia BA | Group F | 0-1 |
| 10/04/25 01:30 | Club Bolívar | Sporting Cristal | Group G | 3-0 |
| 10/04/25 01:30 | Palmeiras | Club Cerro Porteno | Group G | 1-0 |
| 10/04/25 01:30 | Flamengo | Central Cordoba | Group C | 1-2 |
| 10/04/25 03:00 | LDU Quito | Deportivo Tachira | Group C | 2-0 |
| 10/04/25 23:00 | Internacional | Atlético Nacional | Group F | 3-0 |
| 10/04/25 23:00 | Racing Club | Atlético Bucaramanga | Group E | 1-2 |
| Cancelled | Colo-Colo | Fortaleza | Group E | 0-0 |
| 11/04/25 01:30 | FC Sao Paulo | Alianza Lima | Group D | 2-2 |